ADH1B, ADH1B/C and CYP2E1 Gene Polymorphism and the Risk of Fetal Alcohol Spectrum Disorder

Increasing alcohol consumption by women of childbearing age contributes to more frequent cases fetal spectrum disorder. The cause the syndrome is exposure, particularly what referred as high prenatal exposure. Low metabolic activity enzymes shifts burden ethanol removal maternal metabolism. One factors influencing pathogenesis FASD genetic background. It can determine rate elimination ethanol, thus increasing or decreasing time exposure and also its concentration. Genetic polymorphisms could potentially play a significant role in these processes. In present study, we considered three genes implicated synthesis involved metabolism, i.e., ADH1b (rs1229984), ADH1b/c (rs1789891), CYP2E1 (rs3813867). studied group consisted 303 children 251 mothers. Both mothers’ children’s genotypes were our analysis. There no statistically differences between respective groups polymorphisms. However, background still elusive.